Polycystic Kidney Disease

About Jinghua HuYong Yu

Jinghua Hu is an Associate Professor in Biochemistry and Molecular Biology at the Mayo Clinic in Rochester Minnesota. He uses various model systems to study the correlation between cilia dysfunction and cilia-related diseases (collectively known as ciliopathies). The long-term goals of Dr. Hu's laboratory are to understand how cilia form and function; determine the pathogenesis underlying ciliopathies; and design therapies to prevent delay or halt disease progression. The major experimental approaches used in Dr. Hu's laboratory include molecular genetics biochemistry real-time imaging and model organisms. Dr. Hu's research has been funded by the National Institutes of Health and PKD Foundation among other organizations. Yong Yu is an Associate Professor and Graduate Director for Biological Sciences Molecular and Cellular Physiology and Neurobiology at St Johns University. The research in Yu lab is focusing on the molecular mechanisms of assembly function and regulation of ion channels and membrane receptors. Currently they are interested in the transient receptor potential (TRP) channels proteins which are essential for sensory physiology and have been shown to play crucial roles in human diseases. So far TRP channels has been shown to be involved in the formation of sight hearing touch smell taste temperature and pain sensation. They use cultured mammalian cells Xenopus oocytes and zebrafish as model systems and study structure and function of ion channels and receptors with a combined molecular biology biochemistry biophysics x-ray crystallography and electrophysiology approach. Research in Yu lab is funded by the National Institutes of Health.