Aquaporins in Health and Disease: New Molecular Targets for Drug Discovery

About

Graça Soveral is an associate professor in the Pharmacy School at the University of Lisbon and principal investigator at the Research Institute for Medicines (iMed.ULisboa) where she coordinates the Biological Transport Unit. She received a PhD in pharmacy sub-area biochemistry from the University of Lisbon. Her main research area is membrane transport with a special emphasis on water and solute transport in cell physiology and osmoregulation aquaporin gating and the discovery of aquaporin modulators for diagnostic and therapeutic applications. Søren Nielsen is a professor in the Department of Health Science and Technology at Aalborg University. He received an MD and a dr.med.sci degree in medical sciences from Aarhus University. His research involves the cell and molecular biological physiological and pathophysiological studies of aquaporin membrane water channels (aquaporins) sodium channels and transporters in kidney and other organs to explore their role in water and sodium balance regulation in health and disease.Angela Casini is the chair of medicinal and bioinorganic chemistry in the School of Chemistry at Cardiff University. She received a PhD in chemistry from the University of Florence. Her work in medicinal and bioinorganic chemistry focuses on the study of the molecular mechanisms of anticancer metallodrugs and the development of metal compounds as chemical probes to detect protein functions. Peter Agre co-authored the preface of this book. He is a professor and director of the Johns Hopkins Malaria Research Institute at Johns Hopkins University. He received an MD from Johns Hopkins University Medical School. Dr. Agre was awarded the 2003 Nobel Prize in Chemistry for his pioneering studies on aquaporins.