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B01=Jean-François Jasmin
B01=Michael P. Lisanti
B01=Philippe Frank
Category1=Non-Fiction
Category=MBGR
Category=MFCC
COP=United States
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Language_English
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Caveolins and Caveolae: Roles in Signaling and Disease Mechanisms

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English

Caveolae are 50-100 nm flask-shaped invaginations of the plasma membrane that are primarily composed of cholesterol and sphingolipids. Using modern electron microscopy techniques, caveolae can be observed as omega-shaped invaginations of the plasma membrane, fully-invaginated caveolae, grape-like clusters of interconnected caveolae (caveosome), or as transcellular channels as a consequence of the fusion of individual caveolae. The caveolin gene family consists of three distinct members, namely Cav-1, Cav-2 and Cav-3. Cav-1 and Cav-2 proteins are usually co-expressed and particularly abundant in epithelial, endothelial, and smooth muscle cells as well as adipocytes and fibroblasts. On the other hand, the Cav-3 protein appears to be muscle-specific and is therefore only expressed in smooth, skeletal and cardiac muscles. Caveolin proteins form high molecular weight homo- and/or hetero-oligomers and assume an unusual topology with both their N- and C-terminal domains facing the cytoplasm. See more
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Age Group_Uncategorizedautomatic-updateB01=Jean-François JasminB01=Michael P. LisantiB01=Philippe FrankCategory1=Non-FictionCategory=MBGRCategory=MFCCCOP=United StatesDelivery_Delivery within 10-20 working daysLanguage_EnglishPA=AvailablePrice_€100 and abovePS=Activesoftlaunch
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Product Details
  • Dimensions: 178 x 254mm
  • Publication Date: 30 Jan 2012
  • Publisher: Springer-Verlag New York Inc.
  • Publication City/Country: United States
  • Language: English
  • ISBN13: 9781461412212

About

Jean-François Jasmin PhD obtained his degree at the University of Montreal (Montreal Canada) in 2004. From 2004 to 2007 he was a Post-Doctoral Fellow at both the Albert Einstein College of Medicine (Bronx NY; Department of Molecular Pharmacology) and the Thomas Jefferson University (Philadelphia PA; Department of Cancer Biology). Currently he is an Assistant Professor (Tenure-Track) in the Department of Stem Cell Biology and Regenerative Medicine at the Thomas Jefferson University (Philadelphia PA). The current focus of his laboratory is on the role of caveolin proteins in the development of cardiovascular and pulmonary diseases. Philippe G. Frank PhD obtained his degree in 1998 at the University of Ottawa (Ottawa Canada) under mentor Professor Yves L. Marcel a pioneer in lipoprotein studies. Dr. Franks doctoral dissertation examined the role and function of apolipoprotein A-I in the reverse cholesterol transport pathway. Also in 1998 he continued his career with a post-doctoral fellowship at the Albert Einstein College of Medicine (Bronx NY). There his project focused on the role of caveolin proteins in cancer and atherosclerosis in addition to lipoprotein and cholesterol metabolism. In 2006 he joined the Kimmel Cancer Center as an Assistant Professor at Thomas Jefferson University in Philadelphia Pennsylvania where he focuses on the role of lipoproteins in cancer and vascular diseases. Michael P. Lisanti MD PhD obtained his degrees at Cornell University Medical College (New York NY) in 1992. From 1992-97 he was a Fellow at the Whitehead Institute at MIT (Cambridge MA) affiliated with Dr. Harvey Lodishs laboratory. Currently he is Chairman of the Stem Cell Biology and Regenerative Medicine Department Leader/ Director of the Program in Molecular Biology and Genetics of Cancer and Director of the Stem Cell Biology and Regenerative Medicine Center at the Thomas Jefferson University(Philadelphia PA) as well as Editor-in-Chief of the American Journal of Pathology. The current focus of his laboratory is on the role of caveolin-1 in cancer pathogenesis.

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