Developing Multimodal Therapies for Brain Disorders: Proceedings of a Workshop
English
By (author): and Medicine Board on Health Sciences Policy Engineering Forum on Neuroscience and Nervous System Disorders Health and Medicine Division National Academies of Sciences
Multimodal therapy approaches that combine interventions aimed at different aspects of disease are emerging as potentialand perhaps essentialways to enhance clinical outcomes for patients with psychiatric and neurological disorders. In order to examine the general principles underlying multimodal therapies and to explore challenges, potential barriers, and opportunities for their development, the National Academies of Sciences, Engineering, and Medicine convened a workshop in June 2016. Participants explored scientific, clinical, regulatory, and reimbursement issues related to multimodal approaches and potential opportunities to enhance clinical outcomes for individuals with nervous system disorders. This publication summarizes the presentations and discussions from the workshop.
Table of Contents- Front Matter
- 1 Introduction
- 2 Multimodal Therapy: Overview of Principles, Barriers, and Opportunities
- 3 Exploring the State of the Science
- 4 Regulatory and Reimbursement Considerations
- 5 Trial Designs to Establish Efficacy and Safety in Multimodal Therapies
- 6 Developing Multimodal Therapies: Practical Considerations Relating to Industry
- 7 Role of Research Funders in Multimodal Therapy Development
- Appendix A: References
- Appendix B: Workshop Agenda
- Appendix C: Registered Participants